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[141] A 2015 Public Health England report stated that "Smokers who have tried other methods of quitting without success could be encouraged to try e-cigarettes (EC) to stop smoking and stop smoking services should support smokers using EC to quit by offering them behavioural support." [142] However, since little is known about long term effects, other regulated options such as nicotine replacement therapy, varenicline or bupropion should be discussed primarily
In parallel, with the development of new technologies, human relevant in vitro models for toxicity assessment have been proposed such as three dimensional (3D) advanced models or reconstructed human airway tissues [17, 18]
Rigid packaging formats with tight-fitting lids provide additional protection compared to flexible packaging, though modern stand-up pouches with heat-sealed closures can achieve comparable barrier properties at lower costs
Public Health Education Campaigns - As part of this approach, FDAs Center for Tobacco Products (CTP) is investing in a number of tobacco prevention public education campaigns that directly support our mission by educating the public about the dangers of regulated tobacco products